Current concepts in immunoregulation and pathology of human Chagas disease
نویسندگان
چکیده
منابع مشابه
Chagas disease cardiomyopathy: current concepts of an old disease.
Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as we...
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The kidneys can be damaged by a large number of therapeutic agents. The aim of this article is to discuss the pathological features of drug-induced renal disease as diagnosed by kidney biopsy. The literature is reviewed and cases seen by the authors that have a known drug association are analysed. Mechanisms of injury are varied and all renal structures may be affected. The tubulointerstitial c...
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An apparently paradoxical role for IFN-γ in human Chagas disease was observed when studying the pattern of cytokine production by peripheral blood mononuclear cells (PBMC) obtained from two groups of chagasic patients after specific stimulation with Trypanosoma cruzi-derived antigens. The groups studied were 1) patients treated with benznidazole during the acute phase of Trypanosoma cruzi infe...
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ژورنال
عنوان ژورنال: Current Opinion in Infectious Diseases
سال: 2008
ISSN: 0951-7375
DOI: 10.1097/qco.0b013e3282f88b80